Journal of Organic Chemistry
Journal of Organic Chemistry
5 years ago

Domino Hydroboration/Trifluoromethylation of Alkynes Using Fluoroform-Derived [CuCF3]

Domino Hydroboration/Trifluoromethylation of Alkynes Using Fluoroform-Derived [CuCF3]
Lisi He, Xinkan Yang, Gavin Chit Tsui
A domino hydroboration/trifluoromethylation (formal hydrotrifluoromethylation) of alkynes using the fluoroform-derived [CuCF3] reagent is achieved. Synthetically useful (E)-alkenyl-CF3 building blocks and 1,1-bis(trifluoromethyl)-substituted alkenes can be prepared under ambient conditions in one pot/one step from alkynes. The ultimate source of CF3 is the inexpensive industrial waste fluoroform.

Publisher URL: http://dx.doi.org/10.1021/acs.joc.7b00755

DOI: 10.1021/acs.joc.7b00755

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