5 years ago

An l-RNA Aptamer with Expanded Chemical Functionality that Inhibits MicroRNA Biogenesis

An l-RNA Aptamer with Expanded Chemical Functionality that Inhibits MicroRNA Biogenesis
Jonathan T. Sczepanski, Adam M. Kabza
The inside cover picture shows an in vitro selection strategy for identifying l-RNA aptamers (often referred to as Spiegelmers) containing non-native nucleotides. Using this approach, we identified the first modified l-RNA aptamer (MLRA), which is capable of binding a precursor microRNA (pre-microRNA) hairpin with extremely high affinity and specificity. Binding of the target by the modified aptamer inhibits biogenesis of the corresponding microRNA, thus suggesting that MLRAs offer a robust strategy for targeting structured RNAs for biomedical applications. More information can be found in the communication by J. T. Sczepanski and A. M. Kabza (DOI: 10.1002/cbic.201700362).

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/cbic.201700453

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