3 years ago

Divergent Approach to Thiazolylidene Derivatives: A Perspective on the Synthesis of a Heterocyclic Skeleton from β-Amidothioamides Reactivity

Divergent Approach to Thiazolylidene Derivatives: A Perspective on the Synthesis of a Heterocyclic Skeleton from β-Amidothioamides Reactivity
Stefania Santeusanio, Fabio Mantellini, Roberta Majer, Lucia De Crescentini, Gianluca Giorgi, Gianfranco Favi, Francesca Romana Perrulli
Herein we report a domino protocol able to reach regioselectively thiazolylidene systems by combining the reactive peculiarities of both β-amidothioamides (ATAs) and 1,2-diaza-1,3-dienes (DDs). Depending on the reaction conditions and/or the nature of the residue at C4 of the heterodiene system, ATAs can act as hetero-mononucleophiles or hetero-dinucleophiles in the diversified thiazolylidene ring assembly.

Publisher URL: http://dx.doi.org/10.1021/acs.joc.7b02135

DOI: 10.1021/acs.joc.7b02135

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