5 years ago

Chronic obstructive pulmonary disease candidate gene prioritization based on metabolic networks and functional information

Xilei Zhao, Yuyan Feng, Yuehan He, Xinyan Wang, Lina Chen, Yihua Zhang, Jun Zhang, Wan Li

by Xinyan Wang, Wan Li, Yihua Zhang, Yuyan Feng, Xilei Zhao, Yuehan He, Jun Zhang, Lina Chen

Chronic obstructive pulmonary disease (COPD) is a multi-factor disease, in which metabolic disturbances played important roles. In this paper, functional information was integrated into a COPD-related metabolic network to assess similarity between genes. Then a gene prioritization method was applied to the COPD-related metabolic network to prioritize COPD candidate genes. The gene prioritization method was superior to ToppGene and ToppNet in both literature validation and functional enrichment analysis. Top-ranked genes prioritized from the metabolic perspective with functional information could promote the better understanding about the molecular mechanism of this disease. Top 100 genes might be potential markers for diagnostic and effective therapies.

Publisher URL: http://journals.plos.org/plosone/article

DOI: 10.1371/journal.pone.0184299

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