Accounts of Chemical Research
Accounts of Chemical Research
5 years ago

Development of Selective Peptide Catalysts with Secondary Structural Frameworks

Development of Selective Peptide Catalysts with Secondary Structural Frameworks
Kengo Akagawa, Kazuaki Kudo
Enzymes are biogenic catalysts that enable the vital activity of organisms. Enzymes promote reactions in a selective manner with a high level of substrate recognition ability. The development of such a sophisticated catalyst has been one of the goals for chemists. A synthetic peptide is the prime candidate to realize an enzyme-like catalyst. Considering that the catalytic function of enzymes derives from their molecular structures, the key for the creation of a peptide catalyst might be the introduction of a specific three-dimensional structure. Our motivation was to find a peptide catalyst with a versatile secondary structural framework and apply the peptide to a variety of selective reactions.

Publisher URL: http://dx.doi.org/10.1021/acs.accounts.7b00211

DOI: 10.1021/acs.accounts.7b00211

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