4 years ago

Redox-Neutral Dual Functionalization of Electron-Deficient Alkenes

Redox-Neutral Dual Functionalization of Electron-Deficient Alkenes
Giulia Bergonzini, Carlo Cassani, Carl-Johan Wallentin, Fredrik Pettersson
Visible-light photoredox catalysis has been utilized in a new multicomponent reaction forming β-functionalized δ-diketones under mild conditions in an operationally convenient manner. Single-electron reduction of in situ generated carboxylic acid derivatives forms acyl radicals that react further via 1,2-acylalkylation of olefins in an intermolecular, three-components cascade reaction, giving valuable synthetic entities from readily available starting materials. A diverse set of substrates has been used, demonstrating robust methodology with broad substrate scope. Photoredox catalysis: Acyl radicals have been accessed from simple aromatic carboxylic acids under visible-light photoredox catalysis. The method offers an atom-efficient entry to valuable synthetic entities from readily available starting materials without the need of high-energy UV irradiation, stoichiometric oxidants, high CO pressure, or high temperature.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/chem.201701589

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.