Molecular Pharmacology
Molecular Pharmacology
4 years ago

The Role of ACKR3 in Breast, Lung, and Brain Cancer Function - Minireview]

The Role of ACKR3 in Breast, Lung, and Brain Cancer Function - Minireview]
Maria Neves, Amos Fumagalli, Jelle van den Bor, Philippe Marin, Martine J Smit, Federico Mayor
Recent reports regarding the significance of chemokine receptors in disease have put a spotlight on atypical chemokine receptor 3 (ACKR3). This atypical chemokine receptor is overexpressed in numerous cancer types and has been involved in the modulation of tumor cell proliferation and migration, tumor angiogenesis, or resistance to drugs, thus contributing to cancer progression and metastasis occurrence. Here, we focus on the clinical significance and potential mechanisms underlying the pathologic role of ACKR3 in breast, lung, and brain cancer and discuss its possible relevance as a prognostic factor and potential therapeutic target in these contexts.

Publisher URL: http://molpharm.aspetjournals.org/cgi/content/short/96/6/819

Open URL: http://molpharm.aspetjournals.org/content/molpharm/early/2019/02/11/mol.118.115279.full.pdf

DOI: 10.1124/mol.118.115279

Open access
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