International Journal of Pharmaceutics
International Journal of Pharmaceutics
5 years ago

An in-vitro–in-vivo model for the transdermal delivery of cholecalciferol for the purposes of rodent management

An in-vitro–in-vivo model for the transdermal delivery of cholecalciferol for the purposes of rodent management
The natural selection of anticoagulant resistant rats has resulted in a need for an alternative to anticoagulant rodenticides which differs in both active ingredient and in the method of dosing. Cholecalciferol toxicity to rodents using the dermal route is demonstrated using a variety of penetration enhancing formulations in two in-vitro models and finally in-vivo. A 1ml dose of 50/50 (v/v) DMSO/ethanol containing 15% (v/v) PEG 200 and 20% (w/v) cholecalciferol was judged as ‘sufficiently effective’ in line with the European Union’s Biocidal Products Regulation (No. 528/2012) during in-vivo studies. This dose was found to cause 100% mortality in a rat population in 64.4h (±22h).

Publisher URL: www.sciencedirect.com/science

DOI: S0378517315002719

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