5 years ago

Domain I of the 5′ non-translated genomic region in coxsackievirus B3 RNA is not required for productive replication

Domain I is a cloverleaf-like secondary structure at the 5′ termini of all enterovirus genomes, comprising part of a cis-acting replication element essential for efficient enteroviral replication. 5′ genomic terminal deletions up to as much as 55% of domain I can occur without lethality following coxsackie B virus infections. We report here that the entire CVB structural domain I can be deleted without lethality.

Publisher URL: www.sciencedirect.com/science

DOI: S0042682216301301

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