5 years ago

Inhibitors of cellular kinases with broad-spectrum antiviral activity for hemorrhagic fever viruses

Host cell kinases are important for the replication of a number of hemorrhagic fever viruses. We tested a panel of kinase inhibitors for their ability to block the replication of multiple hemorrhagic fever viruses. OSU-03012 inhibited the replication of Lassa, Ebola, Marburg and Nipah viruses, whereas BIBX 1382 dihydrochloride inhibited Lassa, Ebola and Marburg viruses. BIBX 1382 blocked both Lassa and Ebola virus glycoprotein-dependent cell entry. These compounds may be used as tools to understand conserved virus–host interactions, and implicate host cell kinases that may be targets for broad spectrum therapeutic intervention.

Publisher URL: www.sciencedirect.com/science

DOI: S0166354215001126

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