3 years ago

Helical Polyisocyanopeptides as Lyotropic Liquid Crystals for Measuring Residual Dipolar Couplings

Helical Polyisocyanopeptides as Lyotropic Liquid Crystals for Measuring Residual Dipolar Couplings
Wen Zong, Han Sun, Jiang-Ming Cao, Li Hu, Mao-Lin Hu, Ren Xiang Tan, Xinxiang Lei, Gao-Wei Li
Residual dipolar couplings (RDC) emerged to be an important structural parameter for organic and biomolecules. Herein, a new helical polyisocyanopeptide (l,l-PIAF-OBn) that forms lyotropic liquid crystals (LLC) in CDCl3 is proposed as a novel weakly orienting medium for acquiring residual dipolar couplings (RDCs) of organic molecules. We demonstrate its application for the structural elucidation of strychnine and triptolide. A helical polyisocyanopeptide (l,l-PIAF-OBn) can form lyotropic liquid crystal phases and adopts a strikingly low critical concentration in chloroform. The adjustable alignment medium is easily manipulated and allows the acquisition of residual dipolar couplings (RDCs) for organic molecules.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/chem.201700539

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