3 years ago

Targeted Photodynamic Therapy with a Folate/Sensitizer Assembly Produced from Mesoporous Silica

Targeted Photodynamic Therapy with a Folate/Sensitizer Assembly Produced from Mesoporous Silica
Sabrina Valetti, Adam Feiler, Salvatore Sortino, Chunfang Zhou, Damien Afonso, Venera Cardile, Adriana C. E. Graziano, Sabrina Conoci
A mesoporous silica material prepared by using folic acid (FA) as a template enables the effective encapsulation of meso-tetrakis(4-carboxyphenyl)porphyrin (TCPP) in its interior. Combination of steady-state and time-resolved absorption and emission spectroscopy demonstrate that FA and TCPP are released from the silica material to the aqueous phase in the form of a non-covalent assembly. This assembly does not form by simple mixing of the two components in the absence of silica, suggesting the key role of the material in the assembling process. The FA/TCPP assembly exhibits dual color fluorescence in the visible region, good photosensitization capability of singlet oxygen, and enhanced photo-induced mortality in KB cancer cells overexpressing folate receptor, if compared with the free components. A mesoporous silica material prepared by using folic acid (FA) as a template enables the effective encapsulation of meso-tetrakis(4-carboxyphenyl)porphyrin (TCPP) in its interior. It is demonstrated that FA and TCPP are released from the silica material to the aqueous phase in the form of a non-covalent assembly. The FA/TCPP assembly exhibits dual color fluorescence in the visible region, good photosensitization capability of singlet oxygen, and enhanced photo-induced mortality in KB cancer cells overexpressing folate receptor, if compared with the free components.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/chem.201701432

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