Chemistry - A European Journal
Chemistry - A European Journal
5 years ago

Instantaneous Conversion of [11C]CO2 to [11C]CO via Fluoride-Activated Disilane Species

Instantaneous Conversion of [11C]CO2 to [11C]CO via Fluoride-Activated Disilane Species
Carlotta Taddei, Salvatore Bongarzone, Antony D. Gee
The development of a fast and novel methodology to generate carbon-11 carbon monoxide ([11C]CO) from cyclotron-produced carbon-11 carbon dioxide ([11C]CO2) mediated by a fluoride-activated disilane species is described. This methodology allows up to 74 % conversion of [11C]CO2 to [11C]CO using commercially available reagents, readily available laboratory equipment and mild reaction conditions (room temperature). As proof of utility, radiochemically pure [carbonyl-11C]N-benzylbenzamide was successfully synthesized from produced [11C]CO in up to 74 % radiochemical yield (RCY) and >99 % radiochemical purity (RCP) in ≤10 min from end of [11C]CO2 delivery. Radio Ga Ga: Release of [11C]CO up to 74 % at room temperature within 10 min from the end of [11C]CO2 production.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/chem.201701661

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