Organic Letters
Organic Letters
5 years ago

Pd-Catalyzed Thiophene–Aryl Coupling Reaction via C–H Bond Activation in Deep Eutectic Solvents

Pd-Catalyzed Thiophene–Aryl Coupling Reaction via C–H Bond Activation in Deep Eutectic Solvents
Alessandra Operamolla, Maria A. M. Capozzi, Donato I. Coppi, Francesco Babudri, Angela Punzi, Gianluca M. Farinola, Sergio Matera, Roberta Ragni
Direct arylation of 5-octylthieno[3,4-c]pyrrole-4,6-dione with a series of functionalized aryl iodides via C–H bond activation is demonstrated in a deep eutectic solvent made of choline chloride and urea in non-anhydrous conditions and without exclusion of air. This is the first demonstration of a thiophene–aryl coupling via direct arylation in deep eutectic solvents.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b02114

DOI: 10.1021/acs.orglett.7b02114

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