Organic Letters
Organic Letters
5 years ago

Visible-Light-Mediated Thiol–Ene Reactions through Organic Photoredox Catalysis

Visible-Light-Mediated Thiol–Ene Reactions through Organic Photoredox Catalysis
Sarbjeet Kaur, Gaoyuan Zhao, Ting Wang
Synthetically useful radical thiol–ene reactions can be initiated by visible-light irradiation in the presence of an organic photocatalyst, 9-mesityl-10-methylacridinum tetrafluoroborate. The key thiyl radical intermediates are generated upon quenching of the photoexcited catalyst with a variety of thiols. The success of this method requires only the use of near-stoichiometric levels of alkene coupling partners. Using these highly efficient metal-free conditions, thiol–ene reactions between carbohydrates and peptides can be accomplished in excellent yields.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b01441

DOI: 10.1021/acs.orglett.7b01441

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.