Accounts of Chemical Research
Accounts of Chemical Research
5 years ago

Electron Bifurcation: Thermodynamics and Kinetics of Two-Electron Brokering in Biological Redox Chemistry

Electron Bifurcation: Thermodynamics and Kinetics of Two-Electron Brokering in Biological Redox Chemistry
Carolyn E. Lubner, John W. Peters, David N. Beratan, Paul W. King, Jonathon L. Yuly, Peng Zhang, David W. Mulder
How can proteins drive two electrons from a redox active donor onto two acceptors at very different potentials and distances? And how can this transaction be conducted without dissipating very much energy or violating the laws of thermodynamics? Nature appears to have addressed these challenges by coupling thermodynamically uphill and downhill electron transfer reactions, using two-electron donor cofactors that have very different potentials for the removal of the first and second electron. Although electron bifurcation is carried out with near perfection from the standpoint of energy conservation and electron delivery yields, it is a biological energy transduction paradigm that has only come into focus recently. This Account provides an exegesis of the biophysical principles that underpin electron bifurcation.

Publisher URL: http://dx.doi.org/10.1021/acs.accounts.7b00327

DOI: 10.1021/acs.accounts.7b00327

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