3 years ago

Supramolecular Assembly of Peptide Amphiphiles

Supramolecular Assembly of Peptide Amphiphiles
Mark P. Hendricks, Samuel I. Stupp, Kohei Sato, Liam C. Palmer
Peptide amphiphiles (PAs) are small molecules that contain hydrophobic components covalently conjugated to peptides. In this Account, we describe recent advances involving PAs that consist of a short peptide sequence linked to an aliphatic tail. The peptide sequence can be designed to form β-sheets among the amino acids near the alkyl tail, while the residues farthest from the tail are charged to promote solubility and in some cases contain a bioactive sequence. In water, β-sheet formation and hydrophobic collapse of the aliphatic tails induce assembly of the molecules into supramolecular one-dimensional nanostructures, commonly high-aspect-ratio cylindrical or ribbonlike nanofibers. These nanostructures hold significant promise for biomedical functions due to their ability to display a high density of biological signals on their surface for targeting or to activate pathways, as well as for biocompatibility and biodegradable nature.

Publisher URL: http://dx.doi.org/10.1021/acs.accounts.7b00297

DOI: 10.1021/acs.accounts.7b00297

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