TOR, the Gateway to Cellular Metabolism, Cell Growth, and Disease
Michael N. Hall is this year's recipient of the Lasker Basic Medical Research Award for the identification of the target of rapamycin, TOR. TOR is a master regulator of the cell's growth and metabolic state, and its dysregulation contributes to a variety of diseases, including diabetes, obesity, neurodegenerative disorders, aging, and cancer, making the TOR pathway an attractive therapeutic target.
Publisher URL: http://www.cell.com/cell/fulltext/S0092-8674(17)30944-3
DOI: 10.1016/j.cell.2017.08.019
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