5 years ago

The use of factor Xa inhibitors following opening-wedge high tibial osteotomy for venous thromboembolism prophylaxis

Yoshihiro Kusayama, Masato Aratake, Akihiro Kobayashi, Ryo Ishigatsubo, Ken Kumagai, Yasushi Akamatsu, Shota Mitsuhashi, Hideo Kobayashi, Tomoyuki Saito



This study aimed to investigate the incidence of venous thromboembolism (VTE) after medial opening-wedge high tibial osteotomy (OWHTO) and evaluate the efficacy and safety of edoxaban for the prevention of VTE in patients undergoing OWHTO.


A total of 139 patients with osteoarthritis or osteonecrosis undergoing OWHTO were enrolled in this prospective, randomized study. Four patients were excluded because of preoperatively diagnosed VTE, and 135 patients were divided into two groups—an edoxaban group and a non-edoxaban group—and underwent computed tomography venography on day 7 to check for postoperative VTE. Blood samples were taken on the day before OWHTO and on postoperative days 1, 3, 7, and 14.


Treatment with edoxaban reduced the incidence of VTE after OWHTO; however, there was no statistically significant difference between the two groups. No major bleeding was noted in the edoxaban group. There were significant differences in the D-dimer level, prothrombin time, fibrinogen level, and thrombin antithrombin complex levels between the groups.


Edoxaban is an oral, once-daily, selective, direct factor Xa inhibitor that is safe and easy to handle. It may offer a new option for preventing VTE after OWHTO.

Level of evidence


Publisher URL: https://link.springer.com/article/10.1007/s00167-016-4065-6

DOI: 10.1007/s00167-016-4065-6

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