Biomimetic Synthesis of Lankacidin Antibiotics

Journal of the American Chemical Society

5 years ago

Biomimetic Synthesis of Lankacidin Antibiotics

Ran Hong, Kuan Zheng, Defeng Shen

We devised short syntheses of lankacidinol and lankacyclinol that feature biomimetic Mannich macrocyclization. The modular construction of the carbon framework of these compounds is amenable to rapid structural diversification for the development of antibiotic and antitumor agents.

Publisher URL: http://dx.doi.org/10.1021/jacs.7b08500

DOI: 10.1021/jacs.7b08500

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