3 years ago

Biomimetic Synthesis of Lankacidin Antibiotics

Biomimetic Synthesis of Lankacidin Antibiotics
Ran Hong, Kuan Zheng, Defeng Shen
We devised short syntheses of lankacidinol and lankacyclinol that feature biomimetic Mannich macrocyclization. The modular construction of the carbon framework of these compounds is amenable to rapid structural diversification for the development of antibiotic and antitumor agents.

Publisher URL: http://dx.doi.org/10.1021/jacs.7b08500

DOI: 10.1021/jacs.7b08500

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