3 years ago

Azidofluoroalkylation of Alkenes with Simple Fluoroalkyl Iodides Enabled by Photoredox Catalysis

Azidofluoroalkylation of Alkenes with Simple Fluoroalkyl Iodides Enabled by Photoredox Catalysis
Fengguirong Lin, Xiaoyang Wang, Ning Jiao, Xiaoyu Geng
A mild and efficient protocol for photoredox-catalyzed azidofluoroalkylation of simple alkenes is described with readily available fluoroalkyl iodides. This method allows for a direct and regioselective formation of C–RF and C–N3 bonds from the C═C moiety. A variety of fluoroalkyl groups including the CF3 group can be selectively introduced to olefins to afford a series of β-fluoroalkylated azides.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b02056

DOI: 10.1021/acs.orglett.7b02056

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