3 years ago

Ionic Strength Sensing in Living Cells

Ionic Strength Sensing in Living Cells
Arnold J. Boersma, Bert Poolman, Boqun Liu
Knowledge of the ionic strength in cells is required to understand the in vivo biochemistry of the charged biomacromolecules. Here, we present the first sensors to determine the ionic strength in living cells, by designing protein probes based on Förster resonance energy transfer (FRET). These probes allow observation of spatiotemporal changes in the ionic strength on the single-cell level.

Publisher URL: http://dx.doi.org/10.1021/acschembio.7b00348

DOI: 10.1021/acschembio.7b00348

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