Polymer
Polymer
5 years ago

Synthesis of poly (ethylene glycol)-block-poly (acrylamide)-block-poly (lactide) amphiphilic copolymer through ATRP, ROP and click chemistry: Characterization, micellization and pH-triggered sustained release behaviour

Synthesis of poly (ethylene glycol)-block-poly (acrylamide)-block-poly (lactide) amphiphilic copolymer through ATRP, ROP and click chemistry: Characterization, micellization and pH-triggered sustained release behaviour
pH-responsive amphiphilic triblock copolymer derived from poly (ethylene glycol), poly (acrylamide) and poly (lactide) has been synthesized through the consecutive routes of ATRP, ROP and Click chemistry. Controlled nature of the triblock copolymer has been affirmed by the GPC analysis. Structural property and gelling nature of the copolymer have been investigated using FTIR, 1H/13C NMR spectral analyses and rheological characteristics. The synthesized copolymer is amphiphilic in nature that results to the formation of self-aggregation of the polymeric chains. The nanostructure micelle has been characterized further through AFM, FESEM and HR-TEM analyses. Encapsulation of fluorescence probe guest molecule (pyrene) into copolymer micelle and its release behaviour reveals that it is pH-stimulated and shows sustained release behaviour at pH 7.4.

Publisher URL: www.sciencedirect.com/science

DOI: S0032386117308352

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.