3 years ago

Evaluation of the R2* value in invasive ductal carcinoma with respect to hypoxic-related prognostic factors using iterative decomposition of water and fat with echo asymmetry and least-squares emission (IDEAL)

Yukunori Korogi, Takatoshi Aoki, Shohei Shimajiri, Mari Miyata, Yoshika Nagata, Shunsuke Kinoshita, Takefumi Katsuki, Atsuji Matsuyama, Masami Fujii, Yuzuru Inoue, Yuko Tashima

Abstract

Objective

To correlate the R2* value obtained by iterative decomposition of water and fat with echo asymmetry and least-squares emission (IDEAL) with fibrotic focus (FF), microvessel density and hypoxic biomarker (HIF-1α) in breast carcinoma.

Methods

Forty-two patients who were diagnosed with invasive ductal carcinoma (IDC) of the breast underwent breast MRI including IDEAL before surgery. The entire region of interest (ROI) was delineated on the R2* map, and average tumour R2* value was calculated for each ROI. Histological specimens were evaluated for the presence of FF, the microvessel density (the average microvessel density and the ratio of peripheral to central microvessel density), and the grading of HIF-1α.

Results

FF was identified in 47.6% (20/42) of IDCs. Average R2* value for IDC with FF (42.4±13.2 Hz) was significantly higher than that without FF (28.5±13.9 Hz) (P = 0.01). Spearman rank correlation suggested that the average R2* value correlated with the grade of HIF-1α and the ratio of peripheral to central microvessel density for IDCs (P < 0.001).

Conclusion

Quantification of tumour R2* using IDEAL is associated with the presence of FF and the overexpression of HIF-1α, and may therefore be useful in predicting hypoxia of breast carcinoma.

Key Points

• R2* value obtained by IDEAL correlates with the overexpression of HIF-1α.

• R2* value obtained by IDEAL is associated with fibrotic focus.

• R2* quantification may be useful in predicting hypoxia of breast carcinoma.

Publisher URL: https://link.springer.com/article/10.1007/s00330-017-4832-x

DOI: 10.1007/s00330-017-4832-x

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