European Journal of Radiology
European Journal of Radiology
5 years ago

Prognostic value of tumor necrosis at CT in diffuse large B-cell lymphoma

To determine the prognostic value of tumor necrosis at computed tomography (CT) in newly diagnosed diffuse large B-cell lymphoma (DLBCL). Materials and methods This retrospective study included 51 patients with newly diagnosed DLBCL who had undergone both unenhanced and intravenous contrast-enhanced CT before R-CHOP (rituximab, cyclophosphamide, hydroxydaunorubicin, oncovin and prednisolone) chemo-immunotherapy. Presence of tumor necrosis was visually and quantitatively assessed at CT. Associations between tumor necrosis status at CT and the National Comprehensive Cancer Network (NCCN) International Prognostic Index (IPI) factors were assessed. Cox regression analysis was used to determine the prognostic impact of NCCN-IPI scores and tumor necrosis status at CT. Results There were no correlations between tumor necrosis status at CT and the NCCN-IPI factors categorized age (ρ =−0.042, P =0.765), categorized lactate dehydrogenase (LDH) ratio (ρ =0.201, P =0.156), extranodal disease in major organs (φ =−0.245, P =0.083), Ann Arbor stage III/IV disease (φ =−0.208, P =0.141), and Eastern Cooperative Oncology Group (ECOG) performance status (φ =0.015, P =0.914). In the multivariate Cox proportional hazards model, only tumor necrosis status at CT was an independent predictive factor of progression-free survival (P =0.003) and overall survival (P =0.004). Conclusion The findings of this study indicate the prognostic potential of tumor necrosis at CT in newly diagnosed DLBCL.

Publisher URL: www.sciencedirect.com/science

DOI: S0720048X14005786

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.