Journal of Organic Chemistry
Journal of Organic Chemistry
5 years ago

Electrocatalytic C–H/N–H Coupling of 2′-Aminoacetophenones for the Synthesis of Isatins

Electrocatalytic C–H/N–H Coupling of 2′-Aminoacetophenones for the Synthesis of Isatins
Zhiyong Wang, Yukang Wang, Meixiang Bi, Zhenggen Zha, Peng Qian, Ji-Hu Su
2′-Aminoacetophenones undergo a C(sp3)–H oxidation followed by intramolecular C–N bond formation by virtue of a simple electrochemical oxidation in the presence of n-Bu4NI, providing various isatins with moderate to good yields. The reaction intermediates were detected, and a radical-based pathway was proposed.

Publisher URL: http://dx.doi.org/10.1021/acs.joc.7b00635

DOI: 10.1021/acs.joc.7b00635

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