Journal of Biomedical Materials Research - Part A
Journal of Biomedical Materials Research - Part A
5 years ago

Hyaluronic acid-Hydroxyapatite Nanocomposite Hydrogels for Enhanced Biophysical and Biological Performance in a Dermal Matrix

Sukwha Kim, Kwang-Hee Cheon, Jaeuk Baek, Yingfang Fan, Seol-Ha Jeong, Hyoun-Ee Kim
A hyaluronic acid (HAc) - hydroxyapatite (HAp) nanocomposite (HAc-nanoHAp) hydrogel was fabricated through an in situ precipitation process for mechanical and biological enhancement as a soft tissue augmentation product. In this study, these composite hydrogel fillers were analyzed from three different perspectives and compared with pure HAc hydrogel for soft tissue augmentation application: 1) rheological behaviors, 2) in vivo lateral diffusion under mouse skin, and 3) wrinkle improvement in a photo-aged mouse model. HAc-nanoHAp provided great improvement to wrinkles because of its higher stiffness and gel cohesiveness in comparison with that of pure HAc. HAc-nanoHAp also presented great enhancement in strengthening the dermal matrix by stimulating the synthesis of collagen and elastin. Thus, HAc-nanoHAp filler has great potential as a soft tissue augmentation product, improving the biophysical and biological performance in skin tissue. This article is protected by copyright. All rights reserved.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/jbm.a.36190

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