5 years ago

Enantioselective Iridium-Catalyzed Allylic Cyclizations

Enantioselective Iridium-Catalyzed Allylic Cyclizations
Erick M. Carreira, Stephan M. Rummelt, Michael A. Schafroth, David Sarlah
A method for the enantioselective synthesis of carbo- and heterocyclic ring systems enabled through the combination of Lewis acid activation and iridium-catalyzed allylic substitution is described. The reaction proceeds with branched, allylic alcohols and carbon nucleophiles as well as heteronucleophiles to give a diverse set of ring systems in good yields and with high enantioselectivities. The utility of the method is highlighted by the asymmetric syntheses of erythrococcamides A and B.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b01346

DOI: 10.1021/acs.orglett.7b01346

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