3 years ago

Optical Transfer Diagnosis Differentiating Benign and Malignant Pigmented Lesions in a Simulated Primary Care Practice

R. V. Venneugues, S. Q. Vicencio, J. J. Stamnes, G. Ryzhikov, L. Zhao, J. Garioch, M. Biryulina, B. Hamre, F. S. Castellana, K. Stamnes, D. L. Swanson
Background The detection of melanoma poses a substantial challenge, particularly for primary care providers (PCPs) who may have limited training in discriminating between suspicious and benign melanocytic lesions. The noninvasive optical transfer diagnosis (OTD) method was designed to be used by PCPs in their decision-making process. Objectives The aim of this clinical study was to assess the potential of the OTD method by developing, training, and validating an OTD indication algorithm for automated discrimination between benign melanocytic lesions and malignant lesions, based on a set of 712 lesions. Methods The authors performed in vivo OTD capture and subsequent analysis of 712 pigmented lesions. Of the lesions, 415 were clinically and dermoscopically benign, and 297 were dermoscopically suspicious or equivocal. After image capture, all suspicious or equivocal lesions were biopsied and examined histopathologically. Results Of the 297 suspicious or equivocal lesions, histopathologic findings revealed 80 to be malignant (64 melanomas, 13 basal cell carcinomas, and 3 squamous cell carcinomas). OTD misdiagnosed 1 of the 80 malignant lesions as benign (sensitivity, 99%). The OTD specificity was 93% for the dermoscopically benign lesions, 73% for all lesions included in the study, and 36% for the clinically suspicious, but histopathologically benign lesions. Conclusions High sensitivity and specificity, as provided by OTD in this preliminary study, would help PCPs reduce the number of referrals for dermatology consultation, excision, or biopsy. Further studies are planned for screening patients in a primary care setting, with comparisons of OTD results to biopsy or dermoscopy results. This article is protected by copyright. All rights reserved.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1111/bjd.15898

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.