5 years ago

Dysregulation of inflammatory gene expression in lesional and non-lesional skin of patients with pyoderma gangrenosum

J.R. Nunley, S.W. Walsh, O.M. Lucero, S.L. Washington, W.H. Nugent, A.G. Ortega Loayza
Pyoderma gangrenosum (PG) is an inflammatory skin condition that often presents as chronic ulcers. It is often idiopathic but can be associated with systemic conditions1. Our recent publications1,2 highlight the need for better characterization of the molecular understanding of PG to improve diagnostic accuracy and targeted therapy. Recent reviews suggest that innate immunity may have a causative and consequential role in PG. In support of this idea, we reported a possible role for Pattern Recognition Receptors (PRRs) in the pathogenesis of PG 2. To test this hypothesis, paired skin biopsies were collected from lesional and non-lesional (>5 cm from affected area on ipsilateral limb) skin in five patients with PG with clinically active disease. This article is protected by copyright. All rights reserved.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1111/bjd.15837

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