British Journal of Dermatology
British Journal of Dermatology
5 years ago

Appearance of anti-desmocollin 1 autoantibodies leading to a vegetative lesion in a pemphigus vulgaris patient

A. Hamasaka, T. Nomura, Y. Fujita, S. Takashima, N. Ishii, H. Shimizu, H. Ujiie, Y. Yamaguchi, T. Hashimoto, K. Hamasaka, H. Iwata, K. Natsuga, S. Shinkuma
Pemphigus is a group of autoimmune bullous diseases that is mainly classified into pemphigus vulgaris (PV) and pemphigus foliaceus.1 PV is further subcategorized into a mucocutaneous type (with autoantibodies against desmoglein (Dsg) 3 and Dsg1) and a mucosal type (with autoantibodies against Dsg3 but not Dsg1) based on autoantibody profile and clinical features. Pemphigus vegetans (PVeg), a rare variant of PV, is characterized by vegetating lesions. However, the mechanism behind the occurrence of these elevated lesions remains unclear.2 Recently, it was reported that anti-desmocollin (Dsc) 1 and Dsc3 autoantibodies were frequently detected and potentially pathogenic in PVeg.3 Here we report a case of PV in which a vegetative plaque occurred during treatment accompanied by the elevation of anti-Dsc1 autoantibodies. This article is protected by copyright. All rights reserved.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1111/bjd.15834

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