Journal of the European Academy of Dermatology and Venereology
Journal of the European Academy of Dermatology and Venereology
4 years ago

Anti-epileptic drugs induce cutaneous lymphocyte-associated antigen down-regulation leading to potential human Herpes Virus-7 reactivation in clinically asymptomatic patients

P. Malekpour, F. Le Goff, S. Calbo, M. Berard, O. Martinaud, S. Duvert-Lehembre, P. Joly, S. Rogez, E. Houivet, D. Picard, D. Maltete, B. Sabbah, E. Andrieu, F. Caillot, P. Musette
Anti-epileptic drugs (AED) are known to cause cutaneous adverse drug-induced reactions. The pathogenesis of these drug-induced reactions remains poorly understood. In our previous multicenter prospective study, we evidenced reactivation of Epstein-Barr Virus (EBV), Human Herpes Virus 6 (HHV-6) and/or Human Herpes Virus 7 (HHV-7) in 76% of Drug Reaction with Eosinophilia and Systemic Symptom (DRESS) patients. As a consequence of this increased viral antigen exposure, EBV-specific CD8+ T lymphocytes that expressed high levels of Cutaneous Lymphocyte-associated Antigen (CLA) homing markers of skin were found both in blood and in involved organs including skin. This article is protected by copyright. All rights reserved.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1111/jdv.14493

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