5 years ago

Comparative Effectiveness of Once-Weekly GLP-1 Receptor Agonists on 6-Month Glycemic Control and Weight Outcomes in Patients with Type 2 Diabetes

Eric Wittbrodt, Marisa Schauerhamer, Jeff Hurd, Junjie Ma, Sudhir Unni, Natalia Ruiz-Negrón, Carrie McAdam-Marx
A retrospective cohort study was conducted in patients with type 2 diabetes (T2D) in an electronic medical record database to compare real-world, 6-month A1C and weight outcomes for exenatide QW (EQW) vs. dulaglutide and vs. albiglutide. The study included 2,133 EQW, 201 dulaglutide, and 131 albiglutide patients. Overall mean (SD) age was 60 (11) years and 54% were men; neither differed between comparison groups. Mean baseline A1C was similar for EQW [8.3 (1.7)%] and dulaglutide [8.5 (1.5)% (p=0.165)], but higher for albiglutide [8.7 (1.7)% (p<0.001)]. Overall mean A1C change was –0.5 (1.5)% (p<0.001) and did not differ between comparison groups in both adjusted and unadjusted analyses. Mean weight change was –1.4 (4.7) kg for EQW and –1.6 (3.7) kg for albiglutide (p=0.579), but was greater for dulaglutide at –2.7 (5.7) kg (p=0.001). Outcomes were similar in subsets of insulin-naive patients with baseline A1C ≥7.0% or ≥9.0%. All agents significantly reduced A1C at 6 months, with no significant differences between agents or by baseline A1C in insulin-naive subgroups.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1111/dom.13107

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