3 years ago

Bimagrumab improves body composition and insulin sensitivity in insulin-resistant individuals

Lee Anne Filosa, Charles Meyers, Marjorie Zakaria, Olivier Petricoul, Daniel Rooks, Marcus Hompesch, Ronenn Roubenoff, Tania Garito, Didier Laurent, Linda Morrow, Therese Swan, Srikanth Neelakantham, Monte S. Buchsbaum, Katherine Gomez
Aim To test the hypothesis that an improving body composition in insulin-resistant individuals could enhance insulin sensitivity. Methods A total of 16 people with a mean body mass index of 29.3 kg/m2 and insulin resistance, received a single dose of bimagrumab or placebo and were assessed at week 10 for insulin sensitivity, using a hyperinsulinaemic-euglycaemic clamp and an intravenous glucose tolerance test (IVGTT), and for body composition using dual energy X-ray absorptiometry and positron-emission tomography. Results Bimagrumab increased lean mass by 2.7% (P < .05) and reduced fat mass by 7.9% (P = .011) at week 10 compared with placebo, and had a neutral effect on body weight. Bimagrumab reduced glycated haemoglobin by 0.21% at week 18 (P < .001) and improved insulin sensitivity by ~20% (according to the clamp) to ~40% (according to the IVGTT). Conclusion Taking the observed changes together, and given that these occurred without accompanying dietary intervention and without any prescribed regular physical exercise, bimagrumab may offer a novel approach for the treatment of the metabolic complications of obesity.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1111/dom.13042

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