5 years ago

Longitudinal changing values of the sFlt-1/PlGF ratio in singleton pregnancies with early-onset fetal growth restriction

J. Rodriguez-Calvo, I. Herraiz, C. Villalaín, E. Gómez-Montes, A. Galindo, M. S. Quezada
Objective To describe, in singleton pregnancies complicated with early-onset fetal growth restriction (FGR), the progressing values of the sFlt-1/PlGF ratio in the weeks prior to delivery, differentiating cases with and without pre-eclampsia (PE). Methods Prospective cohort observational study of early-onset FGR cases followed with maternal serum determinations of the sFlt-1/PlGF ratio from diagnosis to delivery. Measurements were made at weekly intervals and within the last 48 hours before birth. Absolute values, percentage increases between intervals and previously described cut-off values of 38 (suspicion of PE), 85 (aid in diagnosis of PE), and 655 (high risk for imminent delivery), were used for analysis of the sFlt-1/PlGF ratio. Two groups were compared: FGR (n = 37) vs. FGR + PE (n = 36). Results Overall perinatal survival was 63/73 (86.3%). An sFlt-1/PlGF ratio above 38 were observed four weeks before delivery in most FGR and FGR + PE cases (73% and 100%, respectively), but absolute values of the sFlt-1/PlGF ratio were significantly higher in FGR + PE. Extremely elevated values of the ratio (≥655) within the last 48 hours before delivery were found in 65% of cases of FGR + PE, but only in 8% of isolated FGR cases (p < 0.001). Conclusion Most early-onset FGR show elevated sFlt1/PlGF ratio from four weeks before delivery, and values are even higher if there is a concurrent PE. However, repeated measurements of the ratio have limited value, being only useful to anticipate the need for imminent delivery in the FGR + PE group when values ≥655 are reached.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/uog.18894

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.