3 years ago

Assessment of diastolic function of normal fetal heart using the Dual gate Doppler method

Sumito Nagasaki, Mineto Morita, Rei Ueyama, Mayumi Takano, Masahiko Nakata
Objectives The ratio of mitral peak early diastolic filling to early diastolic mitral annular velocity (E/e') reflects diastolic cardiac function in adults. The Dual gate Doppler (DD) method enables measurements of E/e' in the same heartbeat. This study was designed to assess the utility of the DD method for measurement of fetal E/e', and to determine reference ranges for normal fetuses. Methods This prospective study comprised normal singleton pregnancies between 16 and 36 weeks of gestational age (GA). To calculate fetal E/e', the apical or basal 4-chamber view was demonstrated. Each E wave velocity on pulsed-wave Doppler imaging and each e' wave on tissue Doppler imaging were measured simultaneously according to the DD method. Results A total of 133 pregnancies were included in this study, and all E/e' measurements were successful. Significant correlations were found between GA and left ventricular (LV) E/e' (rs = –0.666, P < 0.001), and between GA and right ventricular (RV) E/e' (rs = –0.607, P < 0.001). The regression equations for bilateral E/e' were as follows: LV-E/e' = 17.341 – 0.631GA + 0.008xGA 2 (R2 = 0.440, SD 1.333); and RV-E/e' = 19.156 – 0.794GA + 0.012GA 2 (R2 = 0.419, SD 1.329). Conclusions Bilateral E/e' of normal fetuses, measured using the DD method, decreased with GA, which is considered related to myocardial maturity. The DD method is useful and convenient for evaluating fetal E/e’ to estimate diastolic function in the prenatal period. Clinical Trial Registration This study was retrospectively registered with Japanese Clinical Trial Registry "UMIN-CTR" on 23 March 2017 (http://www.umin.ac.jp/ctr/index-j.htm) and was given a trial ID number UMIN000026656.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/uog.18821

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.