5 years ago

Prediction of severe pre-eclampsia by a combination of sFlt-1, CT-pro ET1 and blood pressure: exploratory study

Niels Uldbjerg, Anne Lind Malte, Niels Tørring, David Wright
Objectives To evaluate the performance of a combination of clinical-, angiogenic- and vasoactive biomarkers to predict the development of severe preeclampsia (PE) and HELLP syndrome in the third trimester Methods We included 221 women with suspected- , light- , moderate - or severe PE/HELLP (mean gestational age 35+6 weeks) attending the obstetrical outpatient clinic, and 99 with normal pregnancies. Results In a group of patients presenting with mild to moderate symptoms of preeclampsia, a combination of C-terminal Pro Endothelin 1 (CT-Pro-ET1), sFlt-1 and systolic blood pressure reached an Area under Curve (AUC) of 0.94 within one week, and 0.83 within two weeks for the prediction of development of severe PE and HELLP syndrome. The single markers which performed best was CT-Pro-ET-1 (AUC 0.82), sFlt-1 (AUC 0.81) and systolic blood pressure (AUC 0.80), for prediction within one week. Conclusions The performances of CT-Pro-ET1 is very promising, especially in combination with sFlt-1 and systolic blood pressure. However, the findings must be confirmed in further studies.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/uog.17561

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