4 years ago

Prenatal diagnosis of transient abnormal myelopoyesis in three fetuses with Down syndrome: heterogeneous ultrasonographic findings and outcomes

Mauro Stronati, Gianfranco Perotti, Giacomo Fiandrino, Annalisa Rizzo, Arsenio Spinillo, Angela Iasci
Transient abnormal myelopoyesis (TAM) is diagnosed in approximately 10% of babies with Down syndrome (DS), progressing to life-threatening illness in 20% of them. We describe three cases of TAM characterized by heterogeneous ultrasonographic findings and outcomes. The first case was a 27-year-old woman at 32 weeks and 5 days with severe fetal hepatosplenomegaly: liver longitudinal diameter of 78 mm, >2SD (1) and spleen longitudinal diameter of 60 mm, >2SD (2) (Figure 1).

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/uog.17545

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