European Journal of Immunology
European Journal of Immunology
5 years ago

The intestinal microbiota determines the colitis-inducing potential of T-bet-deficient Th cells in mice

Patrick Maschmeyer, Hyun-Dong Chang, Melanie Weber, Jakob Zimmermann, Kerstin Westendorf, Florian Schattenberg, Pawel Durek, René Riedel, Andreas Radbruch, Anja A. Kühl, Francesco Siracusa, Susann Müller, Katrin Lehmann
Conflicting evidence has been provided as to whether induction of intestinal inflammation by adoptive transfer of naïve T cells into Rag−/− mice requires expression of the transcription factor T-bet by the T cells. Here, we formally show that the intestinal microbiota composition of the Rag−/− recipient determines whether or not T-bet-deficient Th cells can induce colitis and we have resolved the differences of the two microbiomes, permissive or non-permissive to T-bet-independent colitis. Our data highlight the dominance of the microbiota over particular T cell differentiation programs in the pathogenesis of chronic intestinal inflammation. This article is protected by copyright. All rights reserved

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/eji.201747100

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