Reduced numbers of circulating group 2 innate lymphoid cells in patients with common variable immunodeficiency

5 years ago

Reduced numbers of circulating group 2 innate lymphoid cells in patients with common variable immunodeficiency

Christoph B. Geier, Sophie Kraupp, Jolan E. Walter, Jocelyn R. Farmer, Hermann M. Wolf, Krisztian Csomos, Martha M. Eibl, David Bra

Recent studies identified an emerging role of group 2 and 3 innate lymphoid cells (ILCs) as key players in the generation of T-dependent and T-independent antibody production. In this retrospective case-control study, CD117+ ILCs (including the majority of ILC2 and ILC3) were reduced in patients with common variable immunodeficiency (CVID). The reduction in CD117+ ILCs was distinctive to CVID and could not be observed in patients with X-linked agammaglobulinemia. Patients with a more pronounced reduction in CD117+ ILC numbers showed significantly lower numbers of peripheral MZ-like B cells and an increased prevalence of chronic, non-infectious enteropathy. Subsequent phenotyping of ILC subsets in CVID revealed that the reduction in CD117+ ILC numbers is due to a reduction in ILC2 numbers. In vitro expansion of CVID ILC2 in response to IL-2, IL-7, IL-25 and IL-33 was impaired. Furthermore, upregulation of MHCII and IL-2RA in response to IL-2, IL-7, IL-25 and IL-33 was impaired in CVID ILC2. Thus, our results indicate a dysregulation of ILC subsets with a reduction in ILC2 numbers in CVID, however, further studies are needed to explore whether ILC abnormalities are a primary finding or secondary to disease complications encountered in CVID. Innate lymphoid cells type 2 are reduced in patients with common variable immunodeficiency. ILC2 deficiency correlates with B-cell abnormalities and chronic enteropathy. CVID ILC2 do not express MCHII and CD25 upon activation.2

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/eji.201746961