5 years ago

Cover Picture: Eur. J. Immunol. 9'17

Cover Picture: Eur. J. Immunol. 9'17
Our front cover features actin structures at the immunological synapse (IS) in primary human CD8+ T cells (CTLs). CTLs were transiently transfected with mCherry (second from top, red), mCherry-tagged profilin1 (PFN1, second from bottom, red) or its mutant Y59A (top/bottom, red). F-actin was stained with phalloidin-Alexa488 (green). The images are taken from Schoppmeyer et al. (pp. 1562–1572), where the authors show that PFN1 is a negative regulator of CTL-mediated killing and lytic granule release. PFN1 modulates CTL migration, protrusion patterns and sustainability, as well as actin structures at the IS. In patients with pancreatic cancer, PFN1 expression is substantially decreased in peripheral CD8+ T cells.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/eji.201770090

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