Immunology
Immunology
5 years ago

Here, there and everywhere: T follicular helper cells on the move

Here, there and everywhere: T follicular helper cells on the move
Tri Giang Phan, Cindy S. Ma
T follicular helper (Tfh) cells have the important function of providing B-cell help for the induction of antigen-specific antibody production. As such, it is important to determine the factors that regulate the development, differentiation and function of Tfh cells. This review highlights some of the recent advances in our understanding of Tfh cell migration, Tfh cell memory and the origins and fate of circulating Tfh cells in the blood, that have been revealed from studies in humans and mice. Schematic showing possible relationship between lymphoid T follicular helper (Tfh) and circulating Tfh (cTfh) cells during a primary (left panel) and secondary (right panel) antibody response.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1111/imm.12793

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