Peripheral perfusion and oxygenation in areas of risk of skin integrity impairment exposed to pressure patterns. A phase I trial (poter study)

5 years ago

Peripheral perfusion and oxygenation in areas of risk of skin integrity impairment exposed to pressure patterns. A phase I trial (poter study)

Marta Aranda-Gallardo, Juan Carlos Morilla-Herrera, Silvia Garcia-Mayor, Shakira Kaknani Uttumchandani, José Miguel Morales-Asencio, Ana Belén Moya-Suárez, Inmaculada Lupiáñez-Pérez, Álvaro Leon Campos

Aim To analyse the changes in peripheral oxygenation and microvascular flow in tissues subjected to different pressure regimes in healthy subjects and in hospitalised patients. Background The presence of pressure ulcers in hospitalised patients is a common complication that has a negative impact on health and often prolongs hospital stay and increases health care costs. Design Experimental non-controlled, non-randomised study in two phases: preclinical and clinical. Methods The preclinical phase will be conducted in healthy volunteers and the clinical phase, in patients at risk of impaired skin integrity. Vascular flow, tissue oxygenation and local temperature in areas at risk of pressure ulcers will be evaluated by Doppler laser in subjects lying on a capacitive surface to measure pressure at 10,249 points. Different levels of pressure will be generated by changes in body position and changes in tissue perfusion and oxygenation will be monitored for up to four hours, to determine the implications for repositioning interventions in patients at risk. This study was funded in July 2015. The protocol is registered in ClinicalTrials. gov (NCT02736838). Discussion Pressure ulcer is a significant and complex health problem in long-term bedridden patients and there is currently no effective treatment or efficient prevention method. The information provided by our study will provide an accurate assessment of different thresholds for the onset of damage to the skin, associated with different body positions and pressure levels. This article is protected by copyright. All rights reserved.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1111/jan.13414