3 years ago

A pH-Responsive DNAsome from the Self-Assembly of DNA–Phenyleneethynylene Hybrid Amphiphile

A pH-Responsive DNAsome from the Self-Assembly of DNA–Phenyleneethynylene Hybrid Amphiphile
Reji Varghese, Nithiyanandan Krishnan, Hari Veera Prasad Thelu, Shine K. Albert, Murali Golla
A pH-responsive DNAsome derived from the amphiphilicity-driven self-assembly of DNA amphiphile containing C-rich DNA sequence is reported. The acidification of DNAsome induces a structural change of C-rich DNA from random coil to an i-motif structure that triggers the disassembly of DNAsome and its subsequent morphological transformation into an open entangled network. The encapsulation of a hydrophobic guest into the membrane of DNAsome and its pH-triggered release upon acidification of DNAsome is also demonstrated. Amphiphilicity-driven self-assembly of DNA amphiphile containing C-rich DNA as the hydrophilic segment leads to the formation of DNAsome at basic pH (7.3). The acidification of DNAsome induces a structural change of C-rich DNA from random coil to an i-motif structure that triggers the disassembly of DNAsome and its subsequent morphological transformation into an open entangled network in a reversible manner.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/chem.201701446

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