Chemistry - A European Journal
Chemistry - A European Journal
5 years ago

Rationally Designed Solvatochromic Fluorescent Indoline Derivatives for Probing Mitochondrial Environment

Rationally Designed Solvatochromic Fluorescent Indoline Derivatives for Probing Mitochondrial Environment
Kaushik Pal, Apurba Lal Koner
A new class of solvatochromic, robust, and multifunctional fluorescent probes derived from indoline is presented. Specificity of mitochondria targeting was achieved and utilized for probing polarity under normal and apoptotic conditions. A large Stokes shift, high quantum yield, thermal, photochemical, and pH stability, tolerance to buffer compositions, and a bioconjugation tool-kit make it a promising candidate for live-cell fluorescence imaging. Looking inside the powerhouse: A new class of solvatochromic fluorescent indoline derivatives is designed and synthesized for bioconjugation and targeting mitochondria to determine polarity under healthy and apoptotic conditions by using spectral scanning microscopy.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/chem.201701425

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