4 years ago

The effect of obesity and repeated exposure on pharmacokinetic response to grape polyphenols in humans

The effect of obesity and repeated exposure on pharmacokinetic response to grape polyphenols in humans
David J. Baer, Sarah K. Gebauer, Lap Ho, Anton I. Terekhov, Giulio M. Pasinetti, Janet A. Novotny, Mario G. Ferruzzi, Tzu-Ying Chen
Scope Evidence suggests that dietary pattern may affect polyphenol absorption and/or metabolism. Further, obesity is associated with lower circulating nutrients, though the reason is unclear. We investigated the pharmacokinetic (PK) response of polyphenols in obese/overweight versus lean individuals before and after repeated dosing of grape polyphenols. Methods and results A pilot study was conducted in which PK challenges were administered before and after 10 days of repeated dosing with polyphenols. Volunteers (6 lean, 6 overweight/obese) consumed resveratrol, grape seed extract, and grape juice (2125 mg total polyphenols) daily. On days 1 and 11, blood samples were collected for 6 h after the polyphenol dose and analyzed for deconjugated catechin, epicatechin, resveratrol, and quercetin. Area under the plasma polyphenol mass by time curves (AUCs) were greater for catechin, epicatechin, and quercetin on day 11 versus day 1 for low BMI individuals (p = 0.039) but not high BMI individuals. Further, AUCs were greater for epicatechin and resveratrol for low versus high BMI individuals (p = 0.041), with a similar trend for catechin (p = 0.065), on day 11 but not day 1. Conclusion These results suggest that that obesity and repeated exposure may modify polyphenol absorption and/or metabolism in humans. Lean and overweight/obese volunteers consumed grape polyphenols for 11 days. On the first and last day of the intervention, a pharmacokinetic challenge was administered. Lean individuals demonstrated a larger plasma polyphenol response after repeated intake of grape polyphenols compared to before repeated intake. Lean individuals also demonstrated a greater plasma response than overweight/obese individuals after repeated polyphenol intake.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/mnfr.201700043

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