Molecular Nutrition and Food Research
Molecular Nutrition and Food Research
5 years ago

Cyanidin-3-glucoside increases whole body energy metabolism by upregulating brown adipose tissue mitochondrial function

Cyanidin-3-glucoside increases whole body energy metabolism by upregulating brown adipose tissue mitochondrial function
Yilin You, Guojie Liu, Qianwen Zhang, Jielong Guo, Wanzhu Jin, Chen Liang, Weidong Huang, Chenglong Ren, Yu Guo, Minghui Meng, Xiangyu Sun, Jicheng Zhan, Tingting Ma, Xiaoxue Yuan, Yuanyuan Huang, Xue Han, Xiaomeng Liu
Scope Obesity develops when energy intake exceeds energy expenditure. Promoting brown adipose tissue (BAT) formation and function increases energy expenditure and may protect against obesity. Cyanidin-3-glucoside (C3G) is an anthocyanin compound that occurs naturally in many fruits and vegetables. In this study, we investigated the effect and mechanism of C3G on the prevention of obesity. Methods and results Db/db mice received C3G dissolved in drinking water for 16 wk; drinking water served as the vehicle treatment. The total body weight, energy intake, metabolic rate, and physical activity were measured. The lipid droplets, gene expression and protein expression were evaluated by histochemical staining, real-time PCR, and western blots. We found that C3G increased energy expenditure, limited weight gain, maintained glucose homeostasis, reversed hepatic steatosis, improved cold tolerance, and enhanced BAT activity in obese db/db mice. C3G also induces brown-like adipocytes (beige) formation in subcutaneous white adipose tissue (sWAT) of db/db mice model. We also found that C3G potently regulates the transcription of uncoupling protein 1 (UCP1) both in BAT and sWAT through increasing mitochondrial number and function. Conclusion Our results suggest that C3G plays a role in regulating systemic energy balance, which may have potential therapeutic implications for the prevention and control of obesity. Cyanidin-3-glucoside (C3G) activates SIRT1, then enhances PGC1-α activity, upregulates TFAM transcriptional activity, and increases mitochondrial biogenesis and function resulting in increased BAT activity and beige formation, and then resisted obesity and diabetes.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/mnfr.201700261

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