5 years ago

Within-person reproducibility and sensitivity to dietary change of C15:0 and C17:0 levels in dried blood spots: Data from the European Food4Me Study

Within-person reproducibility and sensitivity to dietary change of C15:0 and C17:0 levels in dried blood spots: Data from the European Food4Me Study
Lorraine Brennan, Marianne C. Walsh, Yannis Manios, Viviana Albani, J. Alfredo Martinez, Hannelore Daniel, Rodrigo San-Cristobal, Cyril F. M. Marsaux, Christian A. Drevon, Christina P. Lambrinou, Iwona Traczyk, Clare B. O'Donovan, Thomas E. Gundersen, Agnieszka Surwillo, George Moschonis, Carlos Celis-Morales, Ashley J. Adamson, John C. Mathers, Michael J. Gibney, Christina Mavrogianni, Magdalena Godlewska, Santiago Navas-Carretero, Eileen R. Gibney, Rosalind Fallaize, Wim H. M. Saris, Clara Woolhead, Julie A. Lovegrove, Silvia Kolossa, Hannah Forster, Anna L. Macready
Scope Previous work highlighted the potential of odd-chain length saturated fatty acids as potential markers of dairy intake. The aim of this study was to assess the reproducibility of these biomarkers and their sensitivity to changes in dairy intake. Methods and results Fatty acid profiles and dietary intakes from food frequency questionnaires (FFQs) were measured three times over six months in the Food4Me Study. Reproducibility was explored through intra-class correlation coefficients (ICCs) and within-subject coefficients of variation (WCV). Sensitivity to changes in diet was examined using regression analysis. C15:0 blood levels showed high correlation over time (ICC: 0.62, 95% CI: 0.57, 0.68), however, the ICC for C17:0 was much lower (ICC: 0.32, 95% CI: 0.28, 0.46). The WCV for C15:0 was 16.6% and that for C17:0 was 14.6%. There were significant associations between changes in intakes of total dairy, high-fat dairy, cheese and butter and C15:0; and change in intakes of high-fat dairy and cream and C17:0. Conclusion Results provide evidence of reproducibility of C15:0 levels over time and sensitivity to change in intake of high-fat dairy products with results comparable to the well-established biomarker of fish intake (EPA+DHA). Exploration of reproducibility in blood C15:0 and C17:0 levels from repeated measures of dried blood spots indicated good reproducibility for C15:0; and C15:0 levels changed in response to altered high-fat dairy intake.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/mnfr.201700142

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