Molecular Nutrition and Food Research
Molecular Nutrition and Food Research
5 years ago

Grape seed proanthocyanidin extract ameliorates inflammation and adiposity by modulating gut microbiota in high-fat diet mice

Grape seed proanthocyanidin extract ameliorates inflammation and adiposity by modulating gut microbiota in high-fat diet mice
Guang Ning, Yingkai Sun, Jie Hong, Weiqing Wang, Juan Shi, Jiqiu Wang, Shaoqian Zhao, Wen Liu, Ruixin Liu
Scope Obesity and associated metabolic complications is a worldwide public health issue. Gut microbiota have been recently linked to obesity and its related inflammation. In this study, we have explored the anti-inflammatory effect of grape seed proanthocyanindin extract (GSPE) in the high-fat diet (HFD)-induced obesity and identified the contribution of the gut microbiota to GSPE effects on metabolism. Methods and results Mice were fed a normal diet and a high-fat diet with or without GSPE (300 mg/kg body weight/day) by oral gavage for 7 weeks. Supplementation with GSPE significantly decreased plasma levels of inflammatory factors such as TNF-α, IL-6 and MCP-1, companied with ameliorated macrophage infiltration in epidydimal fat and liver tissues. Furthermore, GSPE also reduced epidydimal fat mass and improved insulin sensitivity. 16S rDNA analyses revealed that GSPE supplementation modulated the gut microbiota composition and certain bacteria including Clostridium XIVa, Roseburia and Prevotella. More importantly, depleting gut microbiota by antibiotics treatment abolished the beneficial effects of GSPE on inflammation and adiposity. Conclusion Our study identifies the novel links between gut microbiota alterations and metabolic benefits by GSPE supplementation, providing possibilities for the prevention and treatment of metabolic disorders by targeting gut microbiota through a potential prebiotic agent GSPE. Grape seed proanthocyanidin extract (GSPE) supplementation in HFD-fed mice shows enhanced anti-inflammatory reaction and improved glucose tolerance, accompanied with the modulated gut bacteria community. These changes are mainly characterized by the enhancement of some specific bacterial groups, such as Clostridium XIVa, Roseburia, and Prevotella. More importantly, depleting gut microbiota by antibiotics treatment abolishes the beneficial effects of GSPE on inflammation and adiposity.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/mnfr.201601082

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