5 years ago

Rhodium-Catalyzed Direct Bis-cyanation of Arylimidazo[1,2-α]pyridine via Double C–H Activation

Rhodium-Catalyzed Direct Bis-cyanation of Arylimidazo[1,2-α]pyridine via Double C–H Activation
Shuai Lu, Xin-Qi Hao, Wen-Bo Liu, Zi-Yao Tian, Xiao-Jing Shen, Bing Song, Xinju Zhu, Lu-Lu Tian
An efficient Cp*Rh(III)-catalyzed selective bis-cyanation of arylimidazo[1,2-α]pyridines with N-cyano-N-phenyl-p-methylbenzenesulfonamide via N-directed ortho double C–H activation has been developed. The reaction proceeds with broad functional group tolerance to furnish various cyanated imidazopyridines in high yields. The current methodology exhibits unique characteristics, including high bis-cyanation selectivity, operational convenience, and gram-scale production.

Publisher URL: http://dx.doi.org/10.1021/acs.joc.6b03036

DOI: 10.1021/acs.joc.6b03036

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